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Target
Bcl-2-like protein 1
Ligand
BDBM52889
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL).
IC50
108803±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM52889
Synonyms:
4-(7-hydrocinnamoyloxy-6,8-diketo-7-methyl-isochromen-3-yl)butyric acid methyl ester | 4-[7-methyl-6,8-dioxo-7-(1-oxo-3-phenylpropoxy)-2-benzopyran-3-yl]butanoic acid methyl ester | CMLD004864 | MLS000438876 | SMR000452596 | cid_16745663 | methyl 4-[7-methyl-6,8-bis(oxidanylidene)-7-(3-phenylpropanoyloxy)isochromen-3-yl]butanoate | methyl 4-[7-methyl-6,8-dioxo-7-(3-phenylpropanoyloxy)isochromen-3-yl]butanoate
Type:
Small organic molecule
Emp. Form.:
C24H24O7
Mol. Mass.:
424.4432
SMILES:
COC(=O)CCCC1=CC2=CC(=O)C(C)(OC(=O)CCc3ccccc3)C(=O)C2=CO1 |c:30,t:7,9|
Structure:
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