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Target
Bcl-2-like protein 1
Ligand
BDBM52965
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL).
IC50
27252±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM52965
Synonyms:
1-O-methyl 4-O-(7-methyl-6,8-dioxo-3-thiophen-3-ylisochromen-7-yl) butanedioate | CMLD003572 | MLS000438829 | O1-methyl O4-[7-methyl-6,8-bis(oxidanylidene)-3-thiophen-3-yl-isochromen-7-yl] butanedioate | SMR000452585 | butanedioic acid O1-methyl ester O4-[7-methyl-6,8-dioxo-3-(3-thiophenyl)-2-benzopyran-7-yl] ester | cid_16759464 | succinic acid O4-[6,8-diketo-7-methyl-3-(3-thienyl)isochromen-7-yl] ester O1-methyl ester
Type:
Small organic molecule
Emp. Form.:
C19H16O7S
Mol. Mass.:
388.391
SMILES:
COC(=O)CCC(=O)OC1(C)C(=O)C=C2C=C(OC=C2C1=O)c1ccsc1 |c:15,18,t:13|
Structure:
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