Reaction Details Report a problem with these data
Target
Neuropeptides B/W receptor type 1
Ligand
BDBM62166
Substrate
n/a
Meas. Tech.
Fluorescence-based dose response cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7).
IC50
7864±n/a nM
Citation
 PubChem, PC Fluorescence-based dose response cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). PubChem Bioassay (2010)[AID] 
Target
Name:
Neuropeptides B/W receptor type 1
Synonyms:
GPR7 | NPBW1_HUMAN | NPBWR1 | neuropeptides B/W receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36111.82
Organism:
Homo sapiens (Human)
Description:
gi_119607128
Residue:
328
Sequence:
MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
  
Inhibitor
Name:
BDBM62166
Synonyms:
(5S)-1-[(4-tert-butylcyclohexyl)methyl]-N,N-dimethyl-5-(phenylmethyl)-4,5-dihydroimidazol-2-amine | (5S)-5-benzyl-1-[(4-tert-butylcyclohexyl)methyl]-N,N-dimethyl-4,5-dihydroimidazol-2-amine | MLS001368595 | SMR000752906 | [(5S)-5-benzyl-1-[(4-tert-butylcyclohexyl)methyl]-2-imidazolin-2-yl]-dimethyl-amine | cid_24856242
Type:
Small organic molecule
Emp. Form.:
C23H37N3
Mol. Mass.:
355.56
SMILES:
CN(C)C1=NC[C@H](Cc2ccccc2)N1CC1CCC(CC1)C(C)(C)C |wD:6.6,t:3,(9.86,-6.27,;10.18,-4.76,;11.65,-4.29,;9.04,-3.73,;7.53,-4.05,;6.76,-2.72,;7.79,-1.57,;7.47,-.07,;6.01,.41,;5.69,1.91,;4.22,2.39,;3.08,1.36,;3.4,-.15,;4.86,-.62,;9.2,-2.2,;10.53,-1.43,;10.53,.11,;9.2,.88,;9.2,2.42,;10.53,3.19,;11.87,2.42,;11.87,.88,;10.53,4.73,;10.53,6.27,;12.07,4.73,;8.99,4.73,)|
Structure:
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