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Target
Kappa-type opioid receptor
Ligand
BDBM54777
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay
EC50
3710±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM54777
Synonyms:
MLS000095008 | N-[1-(cyclohexylamino)-2-methyl-1-oxidanylidene-butan-2-yl]-N-(furan-2-ylmethyl)pyrazine-2-carboxamide | N-[1-(cyclohexylamino)-2-methyl-1-oxobutan-2-yl]-N-(2-furanylmethyl)-2-pyrazinecarboxamide | N-[1-(cyclohexylamino)-2-methyl-1-oxobutan-2-yl]-N-(furan-2-ylmethyl)pyrazine-2-carboxamide | N-[1-(cyclohexylcarbamoyl)-1-methyl-propyl]-N-(2-furfuryl)pyrazinamide | SMR000030559 | cid_3242935
Type:
Small organic molecule
Emp. Form.:
C21H28N4O3
Mol. Mass.:
384.472
SMILES:
CCC(C)(N(Cc1ccco1)C(=O)c1cnccn1)C(=O)NC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: