Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM62233
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction revised
IC50
206±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction revised PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM62233
Synonyms:
4-chloranyl-N-(2-methyl-5-nitro-phenyl)-1-oxidanyl-naphthalene-2-carboxamide | 4-chloro-1-hydroxy-N-(2-methyl-5-nitro-phenyl)-2-naphthamide | 4-chloro-1-hydroxy-N-(2-methyl-5-nitrophenyl)-2-naphthalenecarboxamide | 4-chloro-1-hydroxy-N-(2-methyl-5-nitrophenyl)naphthalene-2-carboxamide | MLS-0412039.0001 | cid_2196728
Type:
Small organic molecule
Emp. Form.:
C18H13ClN2O4
Mol. Mass.:
356.76
SMILES:
Cc1ccc(cc1NC(=O)c1cc(Cl)c2ccccc2c1O)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: