Reaction Details
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Delta-type opioid receptor
Ligand
BDBM54821
Substrate
n/a
Meas. Tech.
HTS Image-Based Screen for Agonists of the DOR Receptor
EC50
31191.05±n/a nM
Citation
More Info.:
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
Inhibitor
Name:
BDBM54821
Synonyms:
3-bromanyl-N-[(2S)-1-[(3R,6R)-6-[(4-hydroxyphenyl)methyl]-3-(phenylmethyl)-2,3,5,6-tetrahydroimidazo[1,2-a]imidazol-7-yl]propan-2-yl]-4-methyl-benzamide | 3-bromo-N-[(2S)-1-[(3R,6R)-6-[(4-hydroxyphenyl)methyl]-3-(phenylmethyl)-2,3,5,6-tetrahydroimidazo[1,2-a]imidazol-7-yl]propan-2-yl]-4-methylbenzamide | MLS000697941 | N-[(1S)-2-[(3R,6R)-3-benzyl-6-(4-hydroxybenzyl)-2,3,5,6-tetrahydroimidaz[1,2-a]imidazol-7-yl]-1-methyl-ethyl]-3-bromo-4-methyl-benzamide | N-[(2S)-1-[(3R,6R)-3-benzyl-6-[(4-hydroxyphenyl)methyl]-2,3,5,6-tetrahydroimidazo[1,2-a]imidazol-7-yl]propan-2-yl]-3-bromo-4-methylbenzamide | SMR000386421 | cid_16195681
Type:
Small organic molecule
Emp. Form.:
C30H33BrN4O2
Mol. Mass.:
561.513
SMILES:
C[C@@H](CN1[C@H](Cc2ccc(O)cc2)CN2[C@H](Cc3ccccc3)CN=C12)NC(=O)c1ccc(C)c(Br)c1 |t:26|
Structure:
