Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM62184
Substrate
n/a
Meas. Tech.
SAR analysis of Antagonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay
IC50
32000±n/a nM
Citation
 PubChem, PC SAR analysis of Antagonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM62184
Synonyms:
MLS-0425692.0001 | [1-[[1-(3-methylphenyl)-2-imidazolyl]methyl]-4-(2-oxanylmethyl)-4-piperidinyl]methanol | [1-[[1-(3-methylphenyl)imidazol-2-yl]methyl]-4-(oxan-2-ylmethyl)piperidin-4-yl]methanol | [1-[[1-(m-tolyl)imidazol-2-yl]methyl]-4-(tetrahydropyran-2-ylmethyl)-4-piperidyl]methanol | cid_44537711
Type:
Small organic molecule
Emp. Form.:
C23H33N3O2
Mol. Mass.:
383.527
SMILES:
Cc1cccc(c1)-n1ccnc1CN1CCC(CO)(CC2CCCCO2)CC1
Structure:
Search PDB for entries with ligand similarity: