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Target
Delta-type opioid receptor
Ligand
BDBM43416
Substrate
n/a
Meas. Tech.
HTS Image-Based Screen for Antagonists of the DOR Receptor
IC50
6480±n/a nM
Citation
 PubChem, PC HTS Image-Based Screen for Antagonists of the DOR Receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM43416
Synonyms:
MLS000375336 | N-[1-(1-adamantyl)ethyl]-2-(4,5-dichloro-6-keto-pyridazin-1-yl)acetamide | N-[1-(1-adamantyl)ethyl]-2-(4,5-dichloro-6-oxo-1-pyridazinyl)acetamide | N-[1-(1-adamantyl)ethyl]-2-(4,5-dichloro-6-oxopyridazin-1-yl)acetamide | N-[1-(1-adamantyl)ethyl]-2-[4,5-bis(chloranyl)-6-oxidanylidene-pyridazin-1-yl]ethanamide | SMR000254589 | cid_4811966
Type:
Small organic molecule
Emp. Form.:
C18H23Cl2N3O2
Mol. Mass.:
384.3
SMILES:
[H]C12CC3([H])CC([H])(C1)CC(C2)(C3)C(C)NC(=O)Cn1ncc(Cl)c(Cl)c1=O |TLB:8:6:12:1.11.2,8:1:12:6.9.5,THB:5:6:11:3.12.2|
Structure:
Search PDB for entries with ligand similarity: