Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63365
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63365
Synonyms:
MLS000563709 | SMR000388881 | [2-[[2-(1H-indol-3-yl)-2-oxidanylidene-ethyl]amino]-2-oxidanylidene-ethyl] ethanoate | [2-[[2-(1H-indol-3-yl)-2-oxoethyl]amino]-2-oxoethyl] acetate | acetic acid [2-[[2-(1H-indol-3-yl)-2-keto-ethyl]amino]-2-keto-ethyl] ester | acetic acid [2-[[2-(1H-indol-3-yl)-2-oxoethyl]amino]-2-oxoethyl] ester | cid_5461470
Type:
Small organic molecule
Emp. Form.:
C14H14N2O4
Mol. Mass.:
274.272
SMILES:
CC(=O)OCC(=O)NCC(=O)c1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity: