Reaction Details Report a problem with these data
Target
Serine/threonine-protein phosphatase
Ligand
BDBM64791
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for inhibitors of Protein Phosphatase 5 (PP5)
IC50
11006±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of Protein Phosphatase 5 (PP5) PubChem Bioassay (2010)[AID] 
Target
Name:
Serine/threonine-protein phosphatase
Synonyms:
H0YDU8_HUMAN | PPP5C | PPP5C protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55092.68
Organism:
Homo sapiens (Human)
Description:
gi_37589898
Residue:
484
Sequence:
MAEGERTECAEPPRDEPPADGALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVGRPSSGS
  
Inhibitor
Name:
BDBM64791
Synonyms:
4-O-(2-cyclopentyl-3-cyclopropyl-7-methyl-6,8-dioxoisoquinolin-7-yl) 1-O-methyl butanedioate | CMLD003523 | MLS000438592 | O4-[2-cyclopentyl-3-cyclopropyl-7-methyl-6,8-bis(oxidanylidene)isoquinolin-7-yl] O1-methyl butanedioate | SMR000452644 | butanedioic acid O4-(2-cyclopentyl-3-cyclopropyl-7-methyl-6,8-dioxo-7-isoquinolinyl) ester O1-methyl ester | cid_16745570 | succinic acid O4-(2-cyclopentyl-3-cyclopropyl-6,8-diketo-7-methyl-7-isoquinolyl) ester O1-methyl ester
Type:
Small organic molecule
Emp. Form.:
C23H27NO6
Mol. Mass.:
413.4636
SMILES:
COC(=O)CCC(=O)OC1(C)C(=O)C=C2C=C(C3CC3)N(C=C2C1=O)C1CCCC1 |c:22,t:13,15|
Structure:
Search PDB for entries with ligand similarity: