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Target
ATP-dependent molecular chaperone HSP82
Ligand
BDBM64886
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole
EC50
>150000±0 nM
Citation
 PubChem, PC Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole PubChem Bioassay (2010)[AID] 
Target
Name:
ATP-dependent molecular chaperone HSP82
Synonyms:
heat shock protein 90
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80784.12
Organism:
Candida albicans
Description:
gi_994798
Residue:
707
Sequence:
MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEIRDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFTVTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKEVPETEEEDKAAEEDDKKPKLEEVKDEEDEKKEKKTKTVKEEVTETEELNKTKPLWTRNPSDITQDEYNAFYKSISNDWEDPLAVKHFSVEGQLEFRAILFVPKRAPFDAFESKKKKNNIKLYVRRVFITDDAEELIPEWLSFIKGVVDSEDLPLNLSREMLQQNKILKVIRKNIVKKMIETFNEISEDQEQFNQFYTAFSKNIKLGIHEDAQNRQSLAKLLRFYSTKSSEEMTSLSDYVTRMPEHQKNIYYITGESIKAVEKSPFLDALKAKNFEVLFMVDPIDEYAMTQLKEFEDKKLVDITKDFELEESDEEKAAREKEIKEYEPLTKALKDILGDQVEKVVVSYKLVDAPAAIRTGQFGWSANMERIMKAQALRDTTMSSYMSSKKTFEISPSSPIIKELKKKVETDGAEDKTVKDLTTLLFDTALLTSGFTLDEPSNFAHRINRLIALGLNIDDDSEETAVEPEATTTASTDEPAGESAMEEVD
  
Inhibitor
Name:
BDBM64886
Synonyms:
2-Oxo-2H-chromene-3-carboxylic acid cyclopropyl-(3-methoxy-benzyl)-amide | MLS000032630 | N-cyclopropyl-2-keto-N-m-anisyl-chromene-3-carboxamide | N-cyclopropyl-N-[(3-methoxyphenyl)methyl]-2-oxidanylidene-chromene-3-carboxamide | N-cyclopropyl-N-[(3-methoxyphenyl)methyl]-2-oxo-1-benzopyran-3-carboxamide | N-cyclopropyl-N-[(3-methoxyphenyl)methyl]-2-oxochromene-3-carboxamide | SMR000006792 | cid_652092
Type:
Small organic molecule
Emp. Form.:
C21H19NO4
Mol. Mass.:
349.3799
SMILES:
COc1cccc(CN(C2CC2)C(=O)c2cc3ccccc3oc2=O)c1
Structure:
Search PDB for entries with ligand similarity: