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Target
ATP-dependent molecular chaperone HSP82
Ligand
BDBM64915
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole
EC50
>160000±0 nM
Citation
 PubChem, PC Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole PubChem Bioassay (2010)[AID] 
Target
Name:
ATP-dependent molecular chaperone HSP82
Synonyms:
heat shock protein 90
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80784.12
Organism:
Candida albicans
Description:
gi_994798
Residue:
707
Sequence:
MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEIRDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFTVTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKEVPETEEEDKAAEEDDKKPKLEEVKDEEDEKKEKKTKTVKEEVTETEELNKTKPLWTRNPSDITQDEYNAFYKSISNDWEDPLAVKHFSVEGQLEFRAILFVPKRAPFDAFESKKKKNNIKLYVRRVFITDDAEELIPEWLSFIKGVVDSEDLPLNLSREMLQQNKILKVIRKNIVKKMIETFNEISEDQEQFNQFYTAFSKNIKLGIHEDAQNRQSLAKLLRFYSTKSSEEMTSLSDYVTRMPEHQKNIYYITGESIKAVEKSPFLDALKAKNFEVLFMVDPIDEYAMTQLKEFEDKKLVDITKDFELEESDEEKAAREKEIKEYEPLTKALKDILGDQVEKVVVSYKLVDAPAAIRTGQFGWSANMERIMKAQALRDTTMSSYMSSKKTFEISPSSPIIKELKKKVETDGAEDKTVKDLTTLLFDTALLTSGFTLDEPSNFAHRINRLIALGLNIDDDSEETAVEPEATTTASTDEPAGESAMEEVD
  
Inhibitor
Name:
BDBM64915
Synonyms:
(5Z)-5-[5-(3,4-dimethoxyphenyl)-1,2-dihydropyrazol-3-ylidene]-4,7-dimethoxy-1-benzofuran-6-one | (5Z)-5-[5-(3,4-dimethoxyphenyl)-1,2-dihydropyrazol-3-ylidene]-4,7-dimethoxy-6-benzofuranone | (5Z)-5-[5-(3,4-dimethoxyphenyl)-3-pyrazolin-3-ylidene]-4,7-dimethoxy-benzofuran-6-one | MLS000055735 | SMR000060763 | cid_5742487
Type:
Small organic molecule
Emp. Form.:
C21H20N2O6
Mol. Mass.:
396.3933
SMILES:
COc1ccc(cc1OC)-c1cc(n[nH]1)-c1c(O)c(OC)c2occc2c1OC
Structure:
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