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Target
ATP-dependent molecular chaperone HSP82
Ligand
BDBM64923
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole
EC50
421±2671 nM
Citation
 PubChem, PC Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole PubChem Bioassay (2010)[AID] 
Target
Name:
ATP-dependent molecular chaperone HSP82
Synonyms:
heat shock protein 90
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80784.12
Organism:
Candida albicans
Description:
gi_994798
Residue:
707
Sequence:
MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEIRDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFTVTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKEVPETEEEDKAAEEDDKKPKLEEVKDEEDEKKEKKTKTVKEEVTETEELNKTKPLWTRNPSDITQDEYNAFYKSISNDWEDPLAVKHFSVEGQLEFRAILFVPKRAPFDAFESKKKKNNIKLYVRRVFITDDAEELIPEWLSFIKGVVDSEDLPLNLSREMLQQNKILKVIRKNIVKKMIETFNEISEDQEQFNQFYTAFSKNIKLGIHEDAQNRQSLAKLLRFYSTKSSEEMTSLSDYVTRMPEHQKNIYYITGESIKAVEKSPFLDALKAKNFEVLFMVDPIDEYAMTQLKEFEDKKLVDITKDFELEESDEEKAAREKEIKEYEPLTKALKDILGDQVEKVVVSYKLVDAPAAIRTGQFGWSANMERIMKAQALRDTTMSSYMSSKKTFEISPSSPIIKELKKKVETDGAEDKTVKDLTTLLFDTALLTSGFTLDEPSNFAHRINRLIALGLNIDDDSEETAVEPEATTTASTDEPAGESAMEEVD
  
Inhibitor
Name:
BDBM64923
Synonyms:
MLS000056555 | N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-3,5-dimethyl-1-phenyl-4-pyrazolecarboxamide | N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-3,5-dimethyl-1-phenyl-pyrazole-4-carboxamide | N-[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]-3,5-dimethyl-1-phenyl-pyrazole-4-carboxamide | N-[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]-3,5-dimethyl-1-phenylpyrazole-4-carboxamide | SMR000064662 | cid_2533856
Type:
Small organic molecule
Emp. Form.:
C18H15N5O3
Mol. Mass.:
349.3434
SMILES:
Cc1nn(c(C)c1C(=O)Nc1nnc(o1)-c1ccco1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: