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Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM64871
Substrate
n/a
Meas. Tech.
Mode of action - deactivation constant concentration response for ztz240, a potentiator of KCNQ2 potassium channels
EC50
5900±n/a nM
Citation
 PubChem, PC Mode of action - deactivation constant concentration response for ztz240, a potentiator of KCNQ2 potassium channels PubChem Bioassay (2010)[AID] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
  
Inhibitor
Name:
BDBM64871
Synonyms:
N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide | N-(6-chloro-3-pyridinyl)-4-fluorobenzamide | N-(6-chloro-3-pyridyl)-4-fluoro-benzamide | N-(6-chloropyridin-3-yl)-4-fluorobenzamide | US11365181, Compound ZTZ240 | ZTZ240 | cid_3780776
Type:
Small organic molecule
Emp. Form.:
C12H8ClFN2O
Mol. Mass.:
250.656
SMILES:
Fc1ccc(cc1)C(=O)Nc1ccc(Cl)nc1
Structure:
Search PDB for entries with ligand similarity: