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Target
Streptokinase A
Ligand
BDBM54874
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response Followup to Identify Inhibitors of Streptokinase Expression.
EC50
3140±1099 nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response Followup to Identify Inhibitors of Streptokinase Expression. PubChem Bioassay (2010)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM54874
Synonyms:
2-chloranyl-N-[3-cyano-4-(4-methoxyphenyl)sulfanyl-phenyl]benzamide | 2-chloro-N-[3-cyano-4-(4-methoxyphenyl)sulfanylphenyl]benzamide | 2-chloro-N-[3-cyano-4-[(4-methoxyphenyl)thio]phenyl]benzamide | BRD-K40087974-001-04-8 | MLS002699833, ML135 | cid_2769229
Type:
Small organic molecule
Emp. Form.:
C21H15ClN2O2S
Mol. Mass.:
394.874
SMILES:
COc1ccc(Sc2ccc(NC(=O)c3ccccc3Cl)cc2C#N)cc1
Structure:
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