Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM46942
Substrate
n/a
Meas. Tech.
Late stage results from the probe development effort to identify selective agonists of the Transient Receptor Potential Channels 3 (TRPML3)
EC50
1798±n/a nM
Citation
 PubChem, PC Late stage results from the probe development effort to identify selective agonists of the Transient Receptor Potential Channels 3 (TRPML3): fluorescence-based cell-based dose response assay for TRPML3 agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46942
Synonyms:
1-(4-ethoxy-2,3-dimethyl-phenyl)sulfonylpiperidine | 1-(4-ethoxy-2,3-dimethylphenyl)sulfonylpiperidine | 1-[(4-ethoxy-2,3-dimethylphenyl)sulfonyl]piperidine | MLS000693818 | SMR000299866 | cid_976573
Type:
Small organic molecule
Emp. Form.:
C15H23NO3S
Mol. Mass.:
297.413
SMILES:
CCOc1ccc(c(C)c1C)S(=O)(=O)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: