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Target
Inward rectifier potassium channel 2
Ligand
BDBM65858
Substrate
n/a
Meas. Tech.
Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1
IC50
15762±10996 nM
Citation
 PubChem, PC Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 PubChem Bioassay (2010)[AID] 
Target
Name:
Inward rectifier potassium channel 2
Synonyms:
Irk1 | KCNJ2_MOUSE | Kcnj2 | inward rectifier potassium channel 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48383.35
Organism:
Mus musculus
Description:
gi_6680530
Residue:
428
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVSKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
  
Inhibitor
Name:
BDBM65858
Synonyms:
MLS000557943 | N-[2-[5-[(4-chlorobenzyl)thio]-1,3,4-oxadiazol-2-yl]ethyl]carbamic acid tert-butyl ester | N-[2-[5-[(4-chlorophenyl)methylthio]-1,3,4-oxadiazol-2-yl]ethyl]carbamic acid tert-butyl ester | SMR000148659 | cid_1973366 | tert-butyl N-[2-[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate | {2-[5-(4-Chloro-benzylsulfanyl)-[1,3,4]oxadiazol-2-yl]-ethyl}-carbamic acid tert-butyl ester
Type:
Small organic molecule
Emp. Form.:
C16H20ClN3O3S
Mol. Mass.:
369.866
SMILES:
CC(C)(C)OC(=O)NCCc1nnc(SCc2ccc(Cl)cc2)o1
Structure:
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