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Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM65270
Substrate
n/a
Meas. Tech.
Mode of action assay-Automated electrophysiology assay of compounds that potentiate KCNQ2 potassium channel
EC50
7130±5960 nM
Citation
 PubChem, PC Mode of action assay-Automated electrophysiology assay of compounds that potentiate KCNQ2 potassium channel PubChem Bioassay (2010)[AID] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
  
Inhibitor
Name:
BDBM65270
Synonyms:
MLS000705220 | N'-(5-bromo-3-chloro-2-hydroxybenzylidene)-2-phenylacetohydrazide | N'-[(E)-(3-bromanyl-5-chloranyl-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]-2-phenyl-ethanehydrazide | N'-[(E)-(3-bromo-5-chloro-6-keto-cyclohexa-2,4-dien-1-ylidene)methyl]-2-phenyl-acetohydrazide | N'-[(E)-(3-bromo-5-chloro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-2-phenylacetohydrazide | N'-[(E)-(3-bromo-5-chloro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-2-phenylacetohydrazide | SMR000231098 | cid_5332621
Type:
Small organic molecule
Emp. Form.:
C15H12BrClN2O2
Mol. Mass.:
367.625
SMILES:
Oc1c(Cl)cc(Br)cc1C=NNC(=O)Cc1ccccc1 |w:10.11|
Structure:
Search PDB for entries with ligand similarity: