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Target1,5-anhydro-D-fructose reductase
LigandBDBM269287
Substrate/Competitorn/a
Meas. Tech.Fatty Acid Synthase Keto-reductase Domain (FASN KR) Inhibition
pH7.5±n/a
Temperature298.15±n/a K
IC50 214±n/a nM
Commentsextracted
Citation Connolly, PJLu, T Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer US Patent US9718813 Publication Date 8/1/2017
More Info.:Get all data from this article,  Assay Method
 
1,5-anhydro-D-fructose reductase
Name:1,5-anhydro-D-fructose reductase
Synonyms:AF reductase | Aldo-keto reductase family 1 member C-like protein 2 | Aldo-keto reductase family 1 member E2 | LoopADR
Type:Enzyme Catalytic Domain
Mol. Mass.:36595.42
Organism:Homo sapiens (Human)
Description:Q96JD6
Residue:320
Sequence:
MGDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVR
REDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSE
LSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERL
LNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKR
IAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNL
RLAMFPITKNHKDYPFHIEY
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  Blast E-value cutoff:
BDBM269287
NameBDBM269287
Synonyms:1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-2-(2-fluoro-4-(1-methyl-1H-indazol-5-yl)phenyl)-4,4-dimethyl-1H-imidazol-5(4H)-one | US9718813, Compound 32 | US9718813, Compound 69
TypeSmall organic molecule
Emp. Form.C27H28FN5O2
Mol. Mass.473.5419
SMILESCn1ncc2cc(ccc12)-c1ccc(C2=NC(C)(C)C(=O)N2CC2CN(C2)C(=O)C2CC2)c(F)c1 |t:16|
Structure
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