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Target1,5-anhydro-D-fructose reductase
LigandBDBM269325
Substrate/Competitorn/a
Meas. Tech.Fatty Acid Synthase Keto-reductase Domain (FASN KR) Inhibition
pH7.5±n/a
Temperature298.15±n/a K
IC50 107±n/a nM
Commentsextracted
Citation Connolly, PJLu, T Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer US Patent US9718813 Publication Date 8/1/2017
More Info.:Get all data from this article,  Assay Method
 
1,5-anhydro-D-fructose reductase
Name:1,5-anhydro-D-fructose reductase
Synonyms:AF reductase | Aldo-keto reductase family 1 member C-like protein 2 | Aldo-keto reductase family 1 member E2 | LoopADR
Type:Enzyme Catalytic Domain
Mol. Mass.:36595.42
Organism:Homo sapiens (Human)
Description:Q96JD6
Residue:320
Sequence:
MGDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVR
REDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSE
LSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERL
LNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKR
IAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNL
RLAMFPITKNHKDYPFHIEY
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BDBM269325
NameBDBM269325
Synonyms:1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-2-(3-fluoro-4'-(1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-1H-imidazol-5 (4H)-one | US9718813, Compound 70
TypeSmall organic molecule
Emp. Form.C30H32FN5O2
Mol. Mass.513.6058
SMILESCn1cc(cn1)-c1ccc(cc1)-c1ccc(C2=NC(C)(C)C(=O)N2CC2CN(C2)C(=O)C2(C)CC2)c(F)c1 |t:18|
Structure
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