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Target1,5-anhydro-D-fructose reductase
LigandBDBM269340
Substrate/Competitorn/a
Meas. Tech.Fatty Acid Synthase Keto-reductase Domain (FASN KR) Inhibition
pH7.5±n/a
Temperature298.15±n/a K
IC50 158±n/a nM
Commentsextracted
Citation Connolly, PJLu, T Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer US Patent US9718813 Publication Date 8/1/2017
More Info.:Get all data from this article,  Assay Method
 
1,5-anhydro-D-fructose reductase
Name:1,5-anhydro-D-fructose reductase
Synonyms:AF reductase | Aldo-keto reductase family 1 member C-like protein 2 | Aldo-keto reductase family 1 member E2 | LoopADR
Type:Enzyme Catalytic Domain
Mol. Mass.:36595.42
Organism:Homo sapiens (Human)
Description:Q96JD6
Residue:320
Sequence:
MGDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVR
REDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSE
LSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERL
LNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKR
IAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNL
RLAMFPITKNHKDYPFHIEY
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  Blast E-value cutoff:
BDBM269340
NameBDBM269340
Synonyms:(R)-4,4-dimethyl-2-(2-methyl-4-(1-methyl-1H-benzo[d]imidazol-5-yl)phenyl)-1-((1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1H-imidazol-5(4H)-one | US9718813, Compound 85
TypeSmall organic molecule
Emp. Form.C30H35N5O2
Mol. Mass.497.6312
SMILESCc1cc(ccc1C1=NC(C)(C)C(=O)N1C[C@@H]1CCN(C1)C(=O)C1(C)CC1)-c1ccc2n(C)cnc2c1 |r,t:8|
Structure
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