Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM65930
Substrate
n/a
Meas. Tech.
Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel
EC50
152460±1430570 nM
Citation
 PubChem, PC Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel PubChem Bioassay (2011)[AID] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
  
Inhibitor
Name:
BDBM65930
Synonyms:
1-(1,3-benzodioxol-5-yl)-3-(3-pyridinyl)urea | 1-(1,3-benzodioxol-5-yl)-3-(3-pyridyl)urea | 1-(1,3-benzodioxol-5-yl)-3-pyridin-3-yl-urea | 1-(1,3-benzodioxol-5-yl)-3-pyridin-3-ylurea | VU0155960-1 | cid_970916
Type:
Small organic molecule
Emp. Form.:
C13H11N3O3
Mol. Mass.:
257.2447
SMILES:
O=C(Nc1cccnc1)Nc1ccc2OCOc2c1
Structure:
Search PDB for entries with ligand similarity: