Reaction Details
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Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM65944
Substrate
n/a
Meas. Tech.
Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel
EC50
3740±840 nM
Citation
PubChem, PC Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
Inhibitor
Name:
BDBM65944
Synonyms:
1-(6-chloranylpyridin-3-yl)-3-[(2,4-dichlorophenyl)methyl]urea | 1-(6-chloro-3-pyridinyl)-3-[(2,4-dichlorophenyl)methyl]urea | 1-(6-chloro-3-pyridyl)-3-(2,4-dichlorobenzyl)urea | 1-(6-chloropyridin-3-yl)-3-[(2,4-dichlorophenyl)methyl]urea | VU0417928-1 | cid_45489561
Type:
Small organic molecule
Emp. Form.:
C13H10Cl3N3O
Mol. Mass.:
330.597
SMILES:
Clc1ccc(CNC(=O)Nc2ccc(Cl)nc2)c(Cl)c1
Structure:
