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Target
Vacuolar aminopeptidase 1
Ligand
BDBM62224
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits
EC50
16880±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
Vacuolar aminopeptidase 1
Synonyms:
AMPL_YEAST | APE1 | API | LAP4 | YSC1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57084.90
Organism:
Saccharomyces cerevisiae
Description:
gi_486173
Residue:
514
Sequence:
MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
  
Inhibitor
Name:
BDBM62224
Synonyms:
(4,5-dibromo-6-oxopyridazin-1-yl)methyl 2,6-difluorobenzoate | 2,6-difluorobenzoic acid (4,5-dibromo-6-keto-pyridazin-1-yl)methyl ester | 2,6-difluorobenzoic acid (4,5-dibromo-6-oxo-1-pyridazinyl)methyl ester | SR-01000671432 | SR-01000671432-2 | [4,5-bis(bromanyl)-6-oxidanylidene-pyridazin-1-yl]methyl 2,6-bis(fluoranyl)benzoate | cid_1474490
Type:
Small organic molecule
Emp. Form.:
C12H6Br2F2N2O3
Mol. Mass.:
423.992
SMILES:
Fc1cccc(F)c1C(=O)OCn1ncc(Br)c(Br)c1=O
Structure:
Search PDB for entries with ligand similarity: