Reaction Details Report a problem with these data
Target
Vacuolar aminopeptidase 1
Ligand
BDBM66047
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits
EC50
6188±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
Vacuolar aminopeptidase 1
Synonyms:
AMPL_YEAST | APE1 | API | LAP4 | YSC1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57084.90
Organism:
Saccharomyces cerevisiae
Description:
gi_486173
Residue:
514
Sequence:
MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
  
Inhibitor
Name:
BDBM66047
Synonyms:
(3,5-dichloro-2-pyridyl)-[(3-methyl-2-thienyl)methyleneamino]amine | 3,5-bis(chloranyl)-N-[(3-methylthiophen-2-yl)methylideneamino]pyridin-2-amine | 3,5-dichloro-N-[(3-methyl-2-thiophenyl)methylideneamino]-2-pyridinamine | 3,5-dichloro-N-[(3-methylthiophen-2-yl)methylideneamino]pyridin-2-amine | MLS000567748 | SMR000154278 | cid_4831147
Type:
Small organic molecule
Emp. Form.:
C11H9Cl2N3S
Mol. Mass.:
286.18
SMILES:
Cc1ccsc1CN=Nc1ncc(Cl)cc1Cl |w:8.9|
Structure:
Search PDB for entries with ligand similarity: