Reaction Details Report a problem with these data
Target
Vacuolar aminopeptidase 1
Ligand
BDBM58459
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits
EC50
2212±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
Vacuolar aminopeptidase 1
Synonyms:
AMPL_YEAST | APE1 | API | LAP4 | YSC1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57084.90
Organism:
Saccharomyces cerevisiae
Description:
gi_486173
Residue:
514
Sequence:
MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
  
Inhibitor
Name:
BDBM58459
Synonyms:
5-chloranyl-7-[(4-methylphenyl)-(4-methylpiperazin-1-yl)methyl]quinolin-8-ol | 5-chloro-7-[(4-methylphenyl)-(4-methyl-1-piperazinyl)methyl]-8-quinolinol | 5-chloro-7-[(4-methylphenyl)-(4-methylpiperazin-1-yl)methyl]quinolin-8-ol | 5-chloro-7-[(4-methylpiperazino)-(p-tolyl)methyl]quinolin-8-ol | MLS001172768 | SMR000591460 | cid_3878282
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O
Mol. Mass.:
381.898
SMILES:
CN1CCN(CC1)C(c1ccc(C)cc1)c1cc(Cl)c2cccnc2c1O
Structure:
Search PDB for entries with ligand similarity: