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Target
Vacuolar aminopeptidase 1
Ligand
BDBM59078
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits
EC50
1203±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
Vacuolar aminopeptidase 1
Synonyms:
AMPL_YEAST | APE1 | API | LAP4 | YSC1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57084.90
Organism:
Saccharomyces cerevisiae
Description:
gi_486173
Residue:
514
Sequence:
MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
  
Inhibitor
Name:
BDBM59078
Synonyms:
(E)-4-(9,10-dihydrophenanthren-2-yl)-4-keto-but-2-enoic acid | (E)-4-(9,10-dihydrophenanthren-2-yl)-4-oxidanylidene-but-2-enoic acid | (E)-4-(9,10-dihydrophenanthren-2-yl)-4-oxo-2-butenoic acid | (E)-4-(9,10-dihydrophenanthren-2-yl)-4-oxobut-2-enoic acid | MLS001240897 | SMR000841241 | cid_5905739
Type:
Small organic molecule
Emp. Form.:
C18H14O3
Mol. Mass.:
278.302
SMILES:
OC(=O)\C=C\C(=O)c1ccc-2c(CCc3ccccc-23)c1
Structure:
Search PDB for entries with ligand similarity: