Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM66125
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase
IC50
20802±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase PubChem Bioassay (2010)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM66125
Synonyms:
6-Amino-2-m-tolyl-benzo[de]isoquinoline-1,3-dione | 6-amino-2-(3-methylphenyl)benzo[de]isoquinoline-1,3-dione | 6-amino-2-(m-tolyl)benzo[de]isoquinoline-1,3-quinone | 6-azanyl-2-(3-methylphenyl)benzo[de]isoquinoline-1,3-dione | MLS001208168 | SMR000513332 | cid_746686
Type:
Small organic molecule
Emp. Form.:
C19H14N2O2
Mol. Mass.:
302.3267
SMILES:
Cc1cccc(c1)N1C(=O)c2cccc3c(N)ccc(C1=O)c23
Structure:
Search PDB for entries with ligand similarity: