Reaction Details Report a problem with these data
Target
Bcl-2-like protein 11
Ligand
BDBM66356
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis
EC50
>350000±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis PubChem Bioassay (2010)[AID] 
Target
Name:
Bcl-2-like protein 11
Synonyms:
B2L11_HUMAN | BCL2-like 11 isoform 1 | BCL2L11 | BIM
Type:
PROTEIN
Mol. Mass.:
22175.26
Organism:
Homo sapiens (Human)
Description:
EBI_101325
Residue:
198
Sequence:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH
  
Inhibitor
Name:
BDBM66356
Synonyms:
4-[[[(2S)-2-(4-keto-1,2,3-benzotriazin-3-yl)-3-methyl-pentanoyl]amino]methyl]cyclohexanecarboxylic acid | 4-[[[(2S)-3-methyl-1-oxo-2-(4-oxo-1,2,3-benzotriazin-3-yl)pentyl]amino]methyl]-1-cyclohexanecarboxylic acid | 4-[[[(2S)-3-methyl-2-(4-oxidanylidene-1,2,3-benzotriazin-3-yl)pentanoyl]amino]methyl]cyclohexane-1-carboxylic acid | 4-[[[(2S)-3-methyl-2-(4-oxo-1,2,3-benzotriazin-3-yl)pentanoyl]amino]methyl]cyclohexane-1-carboxylic acid | 4-{[(S)-3-Methyl-2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl)-pentanoylamino]-methyl}-cyclohexanecarboxyli c acid | MLS000550950 | SMR000145078 | cid_9551690
Type:
Small organic molecule
Emp. Form.:
C21H28N4O4
Mol. Mass.:
400.4714
SMILES:
CCC(C)[C@@H](C(=O)NCC1CCC(CC1)C(O)=O)n1nnc2ccccc2c1=O |wU:4.18,(13.24,-3.49,;13.24,-1.95,;14.58,-1.18,;15.91,-1.95,;14.58,.36,;13.24,1.13,;13.24,2.67,;11.91,.36,;10.58,1.13,;9.24,.36,;7.91,1.13,;6.57,.36,;6.57,-1.18,;7.91,-1.95,;9.24,-1.18,;5.24,-1.95,;3.91,-1.18,;5.24,-3.49,;15.91,1.13,;15.91,2.67,;17.24,3.44,;18.58,2.67,;19.95,3.49,;21.35,2.7,;21.35,1.1,;19.95,.31,;18.58,1.13,;17.24,.36,;17.24,-1.18,)|
Structure:
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