Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM67191
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
3760±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM67191
Synonyms:
2-chloranyl-N'-(6-chloranylpyridin-2-yl)ethanehydrazide | 2-chloro-N'-(6-chloro-2-pyridinyl)acetohydrazide | 2-chloro-N'-(6-chloro-2-pyridinyl)acetohydrazide | 2-chloro-N'-(6-chloro-2-pyridyl)acetohydrazide | 2-chloro-N'-(6-chloropyridin-2-yl)acetohydrazide | MLS000546455 | SMR000179853 | cid_324450
Type:
Small organic molecule
Emp. Form.:
C7H7Cl2N3O
Mol. Mass.:
220.056
SMILES:
ClCC(=O)NNc1cccc(Cl)n1
Structure:
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