Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM61076
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
>40000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM61076
Synonyms:
MLS000408840 | N-(2,4-dimethylphenyl)-2-[2-[(2-morpholin-4-yl-4-phenyl-1,3-thiazol-5-yl)methylidene]hydrazinyl]-5-nitro-benzenesulfonamide | N-(2,4-dimethylphenyl)-2-[2-[(2-morpholin-4-yl-4-phenyl-1,3-thiazol-5-yl)methylidene]hydrazinyl]-5-nitrobenzenesulfonamide | N-(2,4-dimethylphenyl)-2-[2-[[2-(4-morpholinyl)-4-phenyl-5-thiazolyl]methylidene]hydrazinyl]-5-nitrobenzenesulfonamide | N-(2,4-dimethylphenyl)-2-[N'-[(2-morpholino-4-phenyl-thiazol-5-yl)methylene]hydrazino]-5-nitro-benzenesulfonamide | SMR000243170 | cid_3999453
Type:
Small organic molecule
Emp. Form.:
C28H28N6O5S2
Mol. Mass.:
592.689
SMILES:
Cc1ccc(NS(=O)(=O)c2cc(ccc2N=NCc2sc(nc2-c2ccccc2)N2CCOCC2)[N+]([O-])=O)c(C)c1 |w:15.15|
Structure:
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