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Target
Tumor necrosis factor
Ligand
BDBM67417
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 3
IC50
>20000±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM67417
Synonyms:
4-(2-aminobenzimidazol-1-yl)sulfonylbenzonitrile | 4-(2-azanylbenzimidazol-1-yl)sulfonylbenzenecarbonitrile | 4-[(2-amino-1-benzimidazolyl)sulfonyl]benzonitrile | MLS-0435787.0001 | cid_45253884
Type:
Small organic molecule
Emp. Form.:
C14H10N4O2S
Mol. Mass.:
298.32
SMILES:
Nc1nc2ccccc2n1S(=O)(=O)c1ccc(cc1)C#N
Structure:
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