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Target
Female germline-specific tumor suppressor gld-1
Ligand
BDBM67450
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction
IC50
6631±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction PubChem Bioassay (2010)[AID] 
Target
Name:
Female germline-specific tumor suppressor gld-1
Synonyms:
GLD1_CAEEL | defective in Germ Line Development family member (gld-1) | gld-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50591.33
Organism:
Caenorhabditis elegans
Description:
gi_17507875
Residue:
463
Sequence:
MPSCTTPTYGVSTQLESQSSESPSRSSVMTPTSLDGDNSPRKRFPIIDNVPADRWPSTRRDGWSSVRAPPPARLTLSTNNRHIMSPISSAYSQTPNSLLSPAMFNPKSRSIFSPTLPATPMSYGKSSMDKSLFSPTATEPIEVEATVEYLADLVKEKKHLTLFPHMFSNVERLLDDEIGRVRVALFQTEFPRVELPEPAGDMISITEKIYVPKNEYPDYNFVGRILGPRGMTAKQLEQDTGCKIMVRGKGSMRDKSKESAHRGKANWEHLEDDLHVLVQCEDTENRVHIKLQAALEQVKKLLIPAPEGTDELKRKQLMELAIINGTYRPMKSPNPARVMTAVPLLSPTPLRSSGPVLMSPTPGSGLPSTTFGGSILSPTLTASNLLGSNVFDYSLLSPSMFDSFSSLQLASDLTFPKYPTTTSFVNSFPGLFTSASSFANQTNTNVSPSGASPSASSVNNTSF
  
Inhibitor
Name:
BDBM67450
Synonyms:
(E)-2-cyano-3-[4-(dimethylamino)phenyl]-2-propenoic acid [1-(2-furanylmethylamino)-1-oxopropan-2-yl] ester | (E)-2-cyano-3-[4-(dimethylamino)phenyl]acrylic acid [2-(2-furfurylamino)-2-keto-1-methyl-ethyl] ester | MLS001160854 | SMR000710902 | [1-(furan-2-ylmethylamino)-1-oxidanylidene-propan-2-yl] (E)-2-cyano-3-[4-(dimethylamino)phenyl]prop-2-enoate | [1-(furan-2-ylmethylamino)-1-oxopropan-2-yl] (E)-2-cyano-3-[4-(dimethylamino)phenyl]prop-2-enoate | cid_24688061
Type:
Small organic molecule
Emp. Form.:
C20H21N3O4
Mol. Mass.:
367.3984
SMILES:
CC(OC(=O)C(=C\c1ccc(cc1)N(C)C)\C#N)C(=O)NCc1ccco1
Structure:
Search PDB for entries with ligand similarity: