Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM50306
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
410±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM50306
Synonyms:
(4,6-difluoro-1,3-benzothiazol-2-yl)-([1,3]dioxolo[4,5-f][1,3]benzothiazol-6-yl)amine | MLS000720409 | N-(4,6-difluoro-1,3-benzothiazol-2-yl)-[1,3]dioxolo[4,5-f][1,3]benzothiazol-6-amine | N-[4,6-bis(fluoranyl)-1,3-benzothiazol-2-yl]-[1,3]dioxolo[4,5-f][1,3]benzothiazol-6-amine | SMR000236242 | cid_7110102
Type:
Small organic molecule
Emp. Form.:
C15H7F2N3O2S2
Mol. Mass.:
363.362
SMILES:
Fc1cc(F)c2nc(Nc3nc4cc5OCOc5cc4s3)sc2c1
Structure:
Search PDB for entries with ligand similarity: