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Target
Tyrosine-protein kinase ABL1 [1-999,Q252H]
Ligand
BDBM68208
Substrate
n/a
Meas. Tech.
Biochemcial Assay
pH
7.5±0
IC50
152±0.0 nM
Citation
 Okram, B; Nagle, A; Adrián, FJ; Lee, C; Ren, P; Wang, X; Sim, T; Xie, Y; Wang, X; Xia, G; Spraggon, G; Warmuth, M; Liu, Y; Gray, NS A general strategy for creating "inactive-conformation" abl inhibitors. Chem Biol 13:779-86 (2006) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase ABL1 [1-999,Q252H]
Synonyms:
ABL | ABL1 | ABL1(Q252H) | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL (Phosphorylated) | Tyrosine-protein kinase ABL (dephosphorylated)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
108590.01
Organism:
Homo sapiens (Human)
Description:
gi_62362414
Residue:
999
Sequence:
MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGHYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSS
  
Inhibitor
Name:
BDBM68208
Synonyms:
Type II inhibitor, 2
Type:
Small organic molecule
Emp. Form.:
C24H18F3N5O
Mol. Mass.:
449.4278
SMILES:
Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1nccc(n1)-c1cccnc1
Structure:
Search PDB for entries with ligand similarity: