Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHeat Shock Protein 90 (Hsp90)
LigandBDBM68248
Substrate/Competitorn/a
Meas. Tech.FP Assay
IC50 1.2e+2± 0 nM
Citation Proisy, NSharp, SYBoxall, KConnelly, SRoe, SMProdromou, CSlawin, AMPearl, LHWorkman, PMoody, CJ Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chem Biol13:1203-15 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Heat Shock Protein 90 (Hsp90)
Name:Heat Shock Protein 90 (Hsp90)
Synonyms:82 kDa heat shock protein | ATP-dependent molecular chaperone HSP82 | Heat shock protein Hsp90 heat-inducible isoform
Type:Molecular Chaperone
Mol. Mass.:81369.08
Organism:Saccharomyces cerevisiae
Description:Histidine-tagged yeast HSP90 was transformed into E. coli and purified (>90%) by metal affinity, gel filtration, and ion-exchange chromatography.
Residue:709
Sequence:
MASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEP
DLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQF
GVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDD
QLEYLEEKRIKEVIKRHSEFVAYPIQLVVTKEVEKEVPIPEEEKKDEEKKDEEKKDEDDK
KPKLEEVDEEEEKKPKTKKVKEEVQEIEELNKTKPLWTRNPSDITQEEYNAFYKSISNDW
EDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFESKKKKNNIKLYVRRVFITDEAEDLIPE
WLSFVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQFEKFYSA
FSKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTRMPEHQKNIYYITGESLK
AVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQLKEFEGKTLVDITKDFELEETDEEKAER
EKEIKEYEPLTKALKEILGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRD
SSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTKLLYETALLTSGFSLDE
PTSFASRINRLISLGLNIDEDEETETAPEASTAAPVEEVPADTEMEEVD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM68248
NameBDBM68248
Synonyms:Microlactone, 15a
TypeSmall organic molecule
Emp. Form.C17H19ClO5
Mol. Mass.338.783
SMILESOc1cc(O)c2c(CC(=O)CCCC\C=C\CCOC2=O)c1Cl |t:14|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a