Reaction Details Report a problem with these data
Target
Beta-hexosaminidase subunit alpha
Ligand
BDBM50106194
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
Temperature
298.15±0 K
IC50
1.8e+4± 1.5e+3 nM
Citation
Tropak, MB; Blanchard, JE; Withers, SG; Brown, ED; Mahuran, D High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones. Chem Biol 14:153-64 (2007) [PubMed] Article
More Info.:
Target
Name:
Beta-hexosaminidase subunit alpha
Synonyms:
Beta-N-acetylhexosaminidase subunit alpha | Beta-hexosaminidase subunit alpha (HexA) | HEXA | HEXA_HUMAN
Type:
Protein
Mol. Mass.:
60688.46
Organism:
Homo sapiens (Human)
Description:
P06865
Residue:
529
Sequence:
MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
Inhibitor
Name:
BDBM50106194
Synonyms:
1,3-dioxo-1H-benz[de]isoquinoline | 1,8-Naphthalimide | 1H-benzo[de]isoquinoline-1,3(2H)-dione | BTB12933 | Benzo[de]isoquinoline-1,3-dione | CHEMBL339586
Type:
Small organic molecule
Emp. Form.:
C12H7NO2
Mol. Mass.:
197.1895
SMILES:
O=C1NC(=O)c2cccc3cccc1c23