Reaction Details Report a problem with these data
Target
Glycogen synthase kinase-3 beta
Ligand
BDBM68343
Substrate
n/a
Meas. Tech.
Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity
EC50
>300000±n/a nM
Citation
 PubChem, PC Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity PubChem Bioassay (2010)[AID] 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM68343
Synonyms:
1-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-2-(5-pyridin-4-yl-tetrazol-2-yl)-ethanone | 1-[4-(2-methoxyphenyl)-1-piperazinyl]-2-(5-pyridin-4-yl-2-tetrazolyl)ethanone | 1-[4-(2-methoxyphenyl)piperazin-1-yl]-2-(5-pyridin-4-yl-1,2,3,4-tetrazol-2-yl)ethanone | 1-[4-(2-methoxyphenyl)piperazin-1-yl]-2-(5-pyridin-4-yltetrazol-2-yl)ethanone | 1-[4-(2-methoxyphenyl)piperazino]-2-[5-(4-pyridyl)tetrazol-2-yl]ethanone | MLS000035807 | SMR000003468 | cid_644921
Type:
Small organic molecule
Emp. Form.:
C19H21N7O2
Mol. Mass.:
379.4157
SMILES:
COc1ccccc1N1CCN(CC1)C(=O)Cn1nnc(n1)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: