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Target
Kappa-type opioid receptor
Ligand
BDBM71571
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3
IC50
1830±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM71571
Synonyms:
KSC-5-267C | KUC104151N | N-[2-[(4-methylphenyl)methyl-propan-2-yl-amino]ethyl]-4-[[(3-methylphenyl)sulfonylamino]methyl]benzamide | N-[2-[(4-methylphenyl)methyl-propan-2-ylamino]ethyl]-4-[[(3-methylphenyl)sulfonylamino]methyl]benzamide | N-[2-[isopropyl-(4-methylbenzyl)amino]ethyl]-4-[(m-tolylsulfonylamino)methyl]benzamide | cid_44608029
Type:
Small organic molecule
Emp. Form.:
C28H35N3O3S
Mol. Mass.:
493.661
SMILES:
CC(C)N(CCNC(=O)c1ccc(CNS(=O)(=O)c2cccc(C)c2)cc1)Cc1ccc(C)cc1
Structure:
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