Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM71881
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
>260000±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM71881
Synonyms:
MLS000122434 | N-tert-Butyl-2-{cyclohexyl-[2-(5-thiophen-2-yl-tetrazol-2-yl)-acetyl]-amino}-2-pyridin-4-yl-acetamide | N-tert-butyl-2-[cyclohexyl-[1-oxo-2-(5-thiophen-2-yl-2-tetrazolyl)ethyl]amino]-2-pyridin-4-ylacetamide | N-tert-butyl-2-[cyclohexyl-[2-(5-thiophen-2-yl-1,2,3,4-tetrazol-2-yl)ethanoyl]amino]-2-pyridin-4-yl-ethanamide | N-tert-butyl-2-[cyclohexyl-[2-(5-thiophen-2-yltetrazol-2-yl)acetyl]amino]-2-pyridin-4-ylacetamide | N-tert-butyl-2-[cyclohexyl-[2-[5-(2-thienyl)tetrazol-2-yl]acetyl]amino]-2-(4-pyridyl)acetamide | SMR000119847 | cid_3190096
Type:
Small organic molecule
Emp. Form.:
C24H31N7O2S
Mol. Mass.:
481.614
SMILES:
CC(C)(C)NC(=O)C(N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1cccs1)c1ccncc1
Structure:
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