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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73175
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73175
Synonyms:
6-amino-2-(8-methyl-5-quinolinyl)benzo[de]isoquinoline-1,3-dione | 6-amino-2-(8-methyl-5-quinolyl)benzo[de]isoquinoline-1,3-quinone | 6-amino-2-(8-methylquinolin-5-yl)benzo[de]isoquinoline-1,3-dione | 6-azanyl-2-(8-methylquinolin-5-yl)benzo[de]isoquinoline-1,3-dione | MLS-0311998.0001 | cid_1075260
Type:
Small organic molecule
Emp. Form.:
C22H15N3O2
Mol. Mass.:
353.3734
SMILES:
Cc1ccc(N2C(=O)c3cccc4c(N)ccc(C2=O)c34)c2cccnc12
Structure:
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