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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61360
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
47600±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61360
Synonyms:
1-(Thiophene-2-carbonyl)-piperidine-4-carboxylic acid (2,4-dimethyl-phenyl)-amide | MLS001217275 | N-(2,4-dimethylphenyl)-1-(2-thenoyl)isonipecotamide | N-(2,4-dimethylphenyl)-1-(thiophene-2-carbonyl)piperidine-4-carboxamide | N-(2,4-dimethylphenyl)-1-[oxo(thiophen-2-yl)methyl]-4-piperidinecarboxamide | N-(2,4-dimethylphenyl)-1-thiophen-2-ylcarbonyl-piperidine-4-carboxamide | SMR000611955 | cid_1075533
Type:
Small organic molecule
Emp. Form.:
C19H22N2O2S
Mol. Mass.:
342.455
SMILES:
Cc1ccc(NC(=O)C2CCN(CC2)C(=O)c2cccs2)c(C)c1
Structure:
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