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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73177
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73177
Synonyms:
MLS-0335452.0001 | N-(4-chlorophenyl)-1-(2-thenoyl)isonipecotamide | N-(4-chlorophenyl)-1-(thiophene-2-carbonyl)piperidine-4-carboxamide | N-(4-chlorophenyl)-1-[oxo(thiophen-2-yl)methyl]-4-piperidinecarboxamide | N-(4-chlorophenyl)-1-thiophen-2-ylcarbonyl-piperidine-4-carboxamide | cid_1075548
Type:
Small organic molecule
Emp. Form.:
C17H17ClN2O2S
Mol. Mass.:
348.847
SMILES:
Clc1ccc(NC(=O)C2CCN(CC2)C(=O)c2cccs2)cc1
Structure:
Search PDB for entries with ligand similarity: