Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61352
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
11700±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61352
Synonyms:
5-methyl-6-oxo-3-benzo[b][1,4]benzothiazepinecarboxylic acid ethyl ester | 6-keto-5-methyl-benzo[b][1,4]benzothiazepine-3-carboxylic acid ethyl ester | MLS001200939 | SMR000564429 | cid_4068244 | ethyl 10-methyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate | ethyl 5-methyl-6-oxidanylidene-benzo[b][1,4]benzothiazepine-3-carboxylate | ethyl 5-methyl-6-oxobenzo[b][1,4]benzothiazepine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H15NO3S
Mol. Mass.:
313.371
SMILES:
CCOC(=O)c1ccc2Sc3ccccc3C(=O)N(C)c2c1
Structure:
Search PDB for entries with ligand similarity: