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TargetCytochrome b-245 heavy chain
LigandBDBM67509
Substrate/Competitorn/a
Meas. Tech.Late stage results from the probe development effort to identify inhibitors of (NADPH oxidase 1) NOX1: Family selectivity: Set 2
IC50>50000±n/a nM
Citation PubChem, PC Late stage results from the probe development effort to identify inhibitors of (NADPH oxidase 1) NOX1: Family selectivity: Set 2 PubChem Bioassay(2010)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cytochrome b-245 heavy chain
Name:Cytochrome b-245 heavy chain
Synonyms:CGD91-phox | Cytochrome b(558) subunit beta | Cytochrome b-245, beta polypeptide [Homo sapiens] | Cytochrome b558 subunit beta | Heme-binding membrane glycoprotein gp91phox | NADPH oxidase 2 | NADPH oxidase 2 (NOX2) | NOX2 | Neutrophil cytochrome b 91 kDa polypeptide | Superoxide-generating NADPH oxidase heavy chain subunit | gp91-1 | gp91-phox | p22 phagocyte B-cytochrome
Type:Enzyme
Mol. Mass.:65355.82
Organism:Homo sapiens (Human)
Description:P04839
Residue:570
Sequence:
MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACL
NFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHL
FNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGV
VITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHN
ITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKV
VTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGD
WTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASIL
KSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYL
TGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPE
ALAETLSKQSISNSESGPRGVHFIFNKENF
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  Blast E-value cutoff:
BDBM67509
NameBDBM67509
Synonyms:2,6-dibromo-4-[[(3,5-dichloro-4-pyridinyl)hydrazo]methylidene]-1-cyclohexa-2,5-dienone | 2,6-dibromo-4-[[2-(3,5-dichloropyridin-4-yl)hydrazinyl]methylidene]cyclohexa-2,5-dien-1-one | 2,6-dibromo-4-[[N'-(3,5-dichloro-4-pyridyl)hydrazino]methylene]cyclohexa-2,5-dien-1-one | 4-[[2-[3,5-bis(chloranyl)pyridin-4-yl]hydrazinyl]methylidene]-2,6-bis(bromanyl)cyclohexa-2,5-dien-1-one | SR-03000000731-1 | cid_5703786
TypeSmall organic molecule
Emp. Form.C12H7Br2Cl2N3O
Mol. Mass.439.917
SMILESOc1c(Br)cc(CN=Nc2c(Cl)cncc2Cl)cc1Br |w:8.8|
Structure
n/a