Reaction Details Report a problem with these data
Target
G protein-activated inward rectifier potassium channel 1
Ligand
BDBM73211
Substrate
n/a
Meas. Tech.
Measurement of GPCR-mediated thallium flux through GIRK channels: Dose-Response with Rauwolscine
EC50
2288±n/a nM
Citation
 PubChem, PC Measurement of GPCR-mediated thallium flux through GIRK channels: Dose-Response with Rauwolscine PubChem Bioassay (2010)[AID] 
Target
Name:
G protein-activated inward rectifier potassium channel 1
Synonyms:
Girk1 | KCNJ3_RAT | Kcnj3 | Kga
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56581.73
Organism:
Rattus norvegicus
Description:
gi_13928834
Residue:
501
Sequence:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQGPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEVVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDISTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGPTRMEGNLPAKLRKMNSDRFT
  
Inhibitor
Name:
BDBM73211
Synonyms:
1-(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea | 1-(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)-3-[1,1,1-tris(fluoranyl)-2-(trifluoromethyl)butan-2-yl]urea | 1-[1,1-bis(trifluoromethyl)propyl]-3-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]urea | 1-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea | MLS000038682 | SMR000040744 | cid_659754
Type:
Small organic molecule
Emp. Form.:
C10H12F6N4OS2
Mol. Mass.:
382.349
SMILES:
CCSc1nnc(NC(=O)NC(CC)(C(F)(F)F)C(F)(F)F)s1
Structure:
Search PDB for entries with ligand similarity: