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Target
Polyadenylate-binding protein 1
Ligand
BDBM73206
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (PABP)
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2010)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM73206
Synonyms:
2-[1,5-dimethyl-3-(phenylthio)-2-indolyl]acetic acid ethyl ester | 2-[1,5-dimethyl-3-(phenylthio)indol-2-yl]acetic acid ethyl ester | MLS-0205070.0001 | cid_630907 | ethyl 2-(1,5-dimethyl-3-phenylsulfanyl-indol-2-yl)ethanoate | ethyl 2-(1,5-dimethyl-3-phenylsulfanylindol-2-yl)acetate
Type:
Small organic molecule
Emp. Form.:
C20H21NO2S
Mol. Mass.:
339.451
SMILES:
CCOC(=O)Cc1c(Sc2ccccc2)c2cc(C)ccc2n1C
Structure:
Search PDB for entries with ligand similarity: