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TargetLANA
LigandBDBM74289
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction
EC50>75000±n/a nM
Citation PubChem, PC Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction PubChem Bioassay(2010)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
LANA
Name:LANA
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:131093.36
Organism:Human herpesvirus 8
Description:Q9QR71
Residue:1129
Sequence:
MAPPGMRLRSGRSTGAPLTRGSCRKRNRSPERCDLGDDLHLQPRRKHVADSVDGRECGPH
TLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPV
SPGTTDTHSPSPALPPTQSPESSQRPPLSSPTGRPDSSTPMRPPPSQQTTPPHSPTTPPP
EPPSKSSPDSLAPSTLRSLRKRRLSSPQGPSTLNPICQSPPVSPPRCDFANRSVYPPWAT
ESPIYVGSSSDGDTPPRQPPTSPISIGSSSPSEGSWGDDTAMLVLLAEIAEEASKNEKEC
SENNQAGEDNGDNEISKESQVDKDDNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEED
DEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDEEDGGD
GNKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREPQQRE
PQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQQEPQQQE
PQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQQD
EQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEE
QQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQE
EQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQ
ELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQE
LEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGVEQQEQETV
EEPIILHGSSSEDEMEVDYPVVSTHEQIASSPPGDNTPDDDPQPGPSREYRYVLRTSPPH
RPGVRMRRVPVTHPKKPHPRYQQPPVPYRQIDDCPAKARPQHIFYRRFLGKDGRRDPKCQ
WKFAVIFWGNDPYGLKKLSQAFQFGGVKAGPVSCLPHPGPDQSPITYCVYVYCQNKDTSK
KVQMARLAWEASHPLAGNLQSSIVKFKKPLPLTQPGENQGPGDSPQEMT
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  Blast E-value cutoff:
BDBM74289
n/a
NameBDBM74289
Synonyms:1-[2-(3,4-dimethoxyphenyl)ethyl]-5-oxidanylidene-N-[5-(phenylmethyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide | 1-[2-(3,4-dimethoxyphenyl)ethyl]-5-oxo-N-[5-(phenylmethyl)-1,3,4-thiadiazol-2-yl]-3-pyrrolidinecarboxamide | MLS002180231 | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-1-[2-(3,4-dimethoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-1-homoveratryl-5-keto-pyrrolidine-3-carboxamide | SMR001269261 | cid_25162099
TypeSmall organic molecule
Emp. Form.C24H26N4O4S
Mol. Mass.466.553
SMILESCOc1ccc(CCN2CC(CC2=O)C(=O)Nc2nnc(Cc3ccccc3)s2)cc1OC
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: