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Target
Importin subunit alpha-1
Ligand
BDBM74594
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
37440±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM74594
Synonyms:
2-amino-1-[2-(2-thenoyloxy)ethyl]pyrrolo[3,2-b]quinoxaline-3-carboxylic acid ethyl ester | 2-amino-1-[2-[oxo(thiophen-2-yl)methoxy]ethyl]-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid ethyl ester | MLS000081258 | SMR000044992 | cid_664030 | ethyl 2-amino-1-[2-(thiophene-2-carbonyloxy)ethyl]pyrrolo[3,2-b]quinoxaline-3-carboxylate | ethyl 2-azanyl-1-(2-thiophen-2-ylcarbonyloxyethyl)pyrrolo[3,2-b]quinoxaline-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H18N4O4S
Mol. Mass.:
410.446
SMILES:
CCOC(=O)c1c(N)n(CCOC(=O)c2cccs2)c2nc3ccccc3nc12
Structure:
Search PDB for entries with ligand similarity: