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Target
Importin subunit alpha-1
Ligand
BDBM45650
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>500000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM45650
Synonyms:
(3Z)-1-allyl-5-(morpholin-4-ylsulfonyl)-1H-indole-2,3-dione 3-[N-(2-fluorophenyl)thiosemicarbazone] | 1-(2-fluorophenyl)-3-[(Z)-(5-morpholin-4-ylsulfonyl-2-oxidanylidene-1-prop-2-enyl-indol-3-ylidene)amino]thiourea | 1-(2-fluorophenyl)-3-[(Z)-(5-morpholin-4-ylsulfonyl-2-oxo-1-prop-2-enylindol-3-ylidene)amino]thiourea | 1-(2-fluorophenyl)-3-[(Z)-[5-(4-morpholinylsulfonyl)-2-oxo-1-prop-2-enyl-3-indolylidene]amino]thiourea | 1-[(Z)-(1-allyl-2-keto-5-morpholinosulfonyl-indolin-3-ylidene)amino]-3-(2-fluorophenyl)thiourea | MLS000673604 | SMR000314845 | cid_16194608
Type:
Small organic molecule
Emp. Form.:
C22H22FN5O4S2
Mol. Mass.:
503.57
SMILES:
Fc1ccccc1NC(=S)NN=C1C(=O)N(CC=C)c2ccc(cc12)S(=O)(=O)N1CCOCC1 |w:11.11|
Structure:
Search PDB for entries with ligand similarity: